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Overview

About Charles Holoubek

Whether it is protecting your Trademarks through registration, licensing your copyright, performing a trade secret audit, defending your patent in Federal Court, or serving as local counsel for an infringement claim - Holoubek Law is the Answer.

Practice Areas
Education
SchoolFocusDegreeYear
Franklin Pierce Law CenterIntellectual Property LawJ.D.
Vermont Law SchoolEnvironmental LawM.S.E.L.
Plymouth State CollegeBusiness and FinanceM.B.A.
Dartmouth CollegeBiochemical Engineering Graduate Studies
Louisiana State University - ShreveportBiochemestryB.G.S.

Publications

Publications
TitlePublisherPublished
The End of Business Method Patents?New Hampshire Bar NewsMarch, 2009
A plain language examination of the Federal Circuit's en banc Bilski decision, and how it will affect business innovators.
Patent Law Update - Tafas v Dudas and the Patent Reform ActKeynote lecture presented to the Intellectual Property section of the New Hampshire BarFebruary, 2008
An Open Letter to the 2007 Graduating Class - part 1New Hampshire Bar NewsApril, 2007
An Open Letter to the 2007 Graduating Class - part 2New Hampshire Bar NewsMay, 2007
FBI Found Responsible for Mob Informant's MurderNew Hampshire Trial Bar NewsJuly, 2007
A look into the strategy litigating the complicity of the FBI in the murders of James "Whitey" Bulger and Steve "the Rifleman" Flemmi.
Jury held FBI to task for mob informant's murderNational Law JournalSeptember, 2007
Can an employee's participation in murder fall within the scope of employment for the purposes of establishing civil liability in a wrongful death suit against the employer...
Successful Utilization of Non-Compete AgreementsBusiness NH MagazineOctober, 2007
The Clash Over Corporate CrimeBusiness NH MagazineMay, 2007
An examination of the Justice Department's stance on corporate attorney client privilege.
Working with the DOJ's Policy on Corporate Attorney Client PrivilegeNew Hampshire Bar Association's CLE on Attorney Client PrivilegeMarch, 2007
Market Reaction to Business Method Patents: An Empirical AnalysisComputer Law Review and Technology JournalDecember, 2005
The first empirical analysis of the effect of business method patents.
Inhibition of Na+,K+-ATPase by the cardenolide 6'-O-(E-4-hydroxycinnamoyl) desglucouzarinBiochemical and Biophysical Research CommunicationsOctober, 1998
Among the major cardenolides from the milkweedAsclepias asperula,6?-O-(E-4-hydroxycinnamoyl) desglucouzarin has not been characterized biochemically. In this study, its binding affinity for a physiological receptor, porcine kidney Na+,K+-ATPase, was found to be lower than the other cardenolides in this plant. The order of affinities from highest to lowest was: uzarigenin (Kd= 1.05 ?M) = desglucouzarin (Kd= 0.98 ?M) > uzarin (Kd= 4.0 ?M) > 6?-O-(E-4-hydroxycinnamoyl) desglucouzarin (Kd= 16 ?M). The chemical attachment of the 4-hydroxycinnamoyl group to the 6?-carbon of desglucouzarin significantly inhibits binding. This agrees with predictions that a 5?-methyl group on cardenolides fits the receptor site optimally for the porcine kidney enzyme. The 4-hydroxycinnamic ester was also found to be fluorescent.

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